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Project description

Proton therapy (PT) is an advanced type of radiotherapy used to treat a constantly rising number of cancer patients. PT allows to target tumour with a high accuracy while sparing healthy surrounding tissue from dose. However, changes in anatomy or positioning and organ motion give rise to uncertainties which need to be further minimized to exploit the full benefits of PT. Adapting PT plans in real time has the potential to provide truly personalized treatments, allowing for better target control and less toxicity The main objective of RAPTOR is to advance the proton therapy(PT) for real-time use.

The researchers recruited in RAPTOR will conduct research projects at both academic and non-academic health care facilities which will sharpen their focus on clinical needs with respect to real-time adaptive PT. The active involvement of industry ensures that the transfer of industry-relevant skills is an integral part of individual ESR projects. This will guarantee rapid translation of clinical needs into innovative and marketable solutions.
RAPTOR aims to train a new generation of researchers, enabling a paradigm shift from treatment approaches that are manual and stepwise to those that are automatic and seamless, while assuring standardized clinical implementation of real-time adaptive PT.

The recruited ESRs will acquire a broad range of advanced and transferable skills within a unique, innovative, multidisciplinary and inter-sectoral training environment. Regular training schools and secondments to other EU academic and industrial partners will allow them to develop a broad range of valuable transferable skills.

A total of 15 PhD positions are available at 8 universities, 2 research centres and 3 companies, in the framework of the Horizon 2020 Marie Skłodowska-Curie InnovativeTraining Network (ITN) RAPTOR.

List of PhDs

Dose accumulation and uncertainty estimation

Host: Center of Proton Therapy (CPT) at the Paul Scherrer Institute – PSI, Switzerland.

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Automated segmentation and contour propagation

Host: Faculty of Mathematics and Physics of the University of Ljubljana (UL), Slovenia.

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CBCT enhancement strategies for adaptive ion beam therapy

Host: MedPhoton, Austria.

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Advanced use of Magnetic Resonance Imaging in Adaptive Intensity Modulated Proton Therapy

Host: Cancer Research Center Groningen (CRCG) Research Institute of the University Medical Center Groningen – UMCG, Netherlands.

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4D MR Imaging and motion modelling techniques for adaptive proton therapy

Host: Politecnico di Milano, Italy.

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Optimizing the Plan of the Day

Host: University of Amsterdam, Netherlands.

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Robust optimization for anatomical variations

Host: Aarhus University, Denmark.

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Real-time 4D-dose calculation to assess the efficacy of motion mitigation strategies

Host: GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany.

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Automated and fast machine and delivery log-file based QA

Host: Cosylab, Slovenia.

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Plan approval for daily plan adaptation

Host: Center of Proton Therapy (CPT) at the Paul Scherrer Institute – PSI, Switzerland.

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Robust optimization considering uncertainties in the frame of proton adaptive radiation therapy

Host: Raysearch, Sweden.

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Development of an end-to-end test workflow for all RAPTOR real-time adaptive PT components

Host: Department of Radiation Oncology at the Medical University of Vienna – MedUniVienna, Austria.

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Towards automated prompt-gamma treatment verification: Identification and classification of clinically relevant deviations

Host: National Center for Radiation in Oncology – OncoRay, Germany.

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Dose quantification from PG imaging for adaptive planning

Host: Ludwig-Maximilians-Universität – LMU, Germany.

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Proton Radiography for real-time Intensity Modulated Proton Therapy plan adaptation

Host: Cancer Research Center Groningen (CRCG) Research Institute of the UMCG, Netherlands.

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Towards Interventional Particle Therapy for Advanced Cancer Care