4D MR Imaging and motion modelling techniques for adaptive proton therapy

Host: Politecnico di Milano, Italy.

Planned secondments: CNAO(Italy), GSI (Germany)

Project description

The project will involve the development of strategies based on image guidance and motion modelling for geometric and dosimetric evaluation of respiratory-induced variations in particle therapy, towards treatment optimization and adaptation in moving targets. Specifically, conventional respiratory-correlated Computed Tomography (4DCT) will be complemented by time-resolved and 4D Magnetic Resonance Imaging (4DMRI), allowing radiation-free acquisitions and quantification of anatomo-pathological changes that occur during the treatment workflow. Particular attention will be put on novel image reconstruction methodologies to improve motion description, and on the generation of 4D synthetic CT from acquired 4DMRI data for particle dose calculation. Advanced motion modelling approaches will be also exploited to relate respiratory motion information acquired during treatment with optimal pre-treatment 4D imaging, accounting for both geometric and dosimetric variations. All the implemented strategies will be properly validated to provide an accurate integration of 4D MR-based decision-making and support in a real-time adaptive particle therapy treatment loop.

The student will be enrolled in the PhD training programme in Bioegineering at Politecnico di Milano, under the supervision of Professor Guido Baroni and Dr Chiara Paganelli. The CartCas group of the Bioengineering Division of the Department of Electronics, Information and Bioengineering (DEIB) of the Politecnico di Milano, Milano, Italy, develops technologies and methods for computer assisted technologies with application in high-precision radiation oncology. Specific focus is given to translational research, which is empowered by long-lasting, strategic collaborations with national and international clinical institutions, particularly with the National Center of Oncological Hadrontherapy, Pavia, Italy.

For more information concerning the research project please contact: Chiara Paganelli

Name Surname

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Politecnico Di Milano

PROJECT BENEFICIARY

The CartCas group of the Bioengineering Division of the Department of Electronics, Information and Bioengineering (DEIB) of the Politecnico di Milano works on the development of technologies and methods for computer-assisted technologies with application in high-precision radiation oncology.