Development of an end-to-end test workflow for all RAPTOR real-time adaptive PT components

Host: Department of Radiation Oncology at the Medical University of Vienna – MedUniVienna, Austria.

Planned secondments: UMCG (Groeningen), visits to multiple beneficiaries and partners.

Project description

The aim of this PhD project is to extend currently established static dosimetric end-to-end testing procedures by developing phantoms mimicking real-time adaptive proton therapy conditionsand conducting end-to-end tests for all RAPTOR real-time adaptive proton therapy components.

Core activity is the development and experimental validation of a novel 4D anthropomorphic phantom. The functional requirements and specifications for the purpose-built phantom and the workflows to be covered will be formulated in cooperation with other students and peers in the RAPTOR project. Additionally, the advancement of dosimetry procedures dedicated to the assessment of real-time adaptive proton therapy will be of highest importance. 

All experiments and dosimetric validations will be executed in the synchrotron accelerated proton beam at MedAustron.

The most important aspects in the phantom and workflow development are (1) reproducibility of the phantom movements and organ deformations; (2) simplicity of dosimetric procedures applicable at any proton facility and compatible with all potential imaging systems; (3) reconcilableness of the developed components of a real-time adaptive particle therapy workflow with the clinical requirements. Once all components are ready the complete end-to-end test will be tested by multiple beneficiaries and partners .

The PhD student will be hosted by the Department of Radiation Oncology at the Medical University of Vienna (MedUniVienna) under the supervision of Professor Dietmar Georg.

The MedUniVienna is one of the most traditional medical training and research facilities in Europe with about 8,000 students. Oncology and cancer research as well as medical imaging represent two of its six key focal areas (so called “research cluster”) of research. At present the MedUniVienna offers more than 10 thematic PhD programs which are all held in English. The described PhD project will be assigned to the Medical Physics program.

As far as particle therapy is concerned, the MedUniVienna is closely collaborating with the Austrian Proton- and Ion beam Center MedAustron. Due to this collaboration the PhD student will have (1) free access to a research beam-line for protons and carbon ions including on-line imaging for adaptive ion beam therapy, research treatment planning system for protons and carbon ions; (2) fully equipped Medical Physics and IT/software laboratories and (3) mechanical workshop, dedicated machines and materials for phantom construction.

For more information concerning the research project please contact: Dietmar Georg

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Medizinische Universitat Wien

PROJECT BENEFICIARY

The Medical University of Vienna is one of the oldest medical training and research institutes in Europe. The Department of Radiation Oncology is embedded in the Universities’ focal research areas of oncology and cancer research as well as medical imaging.